Acetyl Hexapeptide-8 (CAS 616204-22-9), commercially known as Argireline, is a premium anti-wrinkle cosmetic peptide consisting of six amino acids. Widely recognized in the global cosmetics market as a safe, non-toxic alternative to Botulinum Toxin (Botox), it targets expression lines and dynamic wrinkles by relaxing facial muscles without the need for invasive injections.
As a leading cosmetic ingredient manufacturer, we provide high-purity, stable-batch Acetyl Hexapeptide-8 powder tailored for high-end anti-aging skincare formulations including serums, eye creams, and anti-wrinkle lotions.
| Parameter | Specification | Test Method |
| CAS Number | 616204-22-9 (or 616204-22-9 free base) | - |
| INCI Name | Acetyl Hexapeptide-8 (Argireline) | International Nomenclature |
| Sequence | Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2 | Peptide Sequence |
| Appearance | White to off-white crystalline powder | Visual |
| Purity (HPLC) | $\ge 98.0\%$ | High-Performance Liquid Chromatography |
| Water Content (Karl Fischer) | $\le 7.0\%$ | KF Titration |
| Acetate Content | $\le 15.0\%$ | HPLC |
| Heavy Metals (Pb, As, Hg, Cd) | $\le 10$ ppm | ICP-MS |
Acetyl Hexapeptide-8 works through a unique mechanism that mimics the N-terminal end of the SNAP-25 protein. As shown in scientific models:
The SNARE Complex Block: It competes with natural SNAP-25 for a position in the SNARE complex, destabilizing this critical protein structure.
Inhibiting Acetylcholine Release: Consequently, it prevents the vesicles from releasing the neurotransmitter acetylcholine into the synaptic cleft.
Muscle Relaxation: Without sufficient acetylcholine signals, facial muscles receive weaker contraction signals, effectively flattening existing expression lines (crow's feet, forehead lines, smile lines) and preventing new ones from forming.
Top-Tier Anti-Wrinkle Efficacy: Clinically proven to reduce the depth of wrinkles around the eyes and forehead by up to 30% within 30 days of continuous application.
High Formulation Stability: Excellent solubility in water, making it effortless to incorporate into cold-process or low-temperature cosmetic phases.
Non-Invasive & Safe: Unlike Botox injections, it poses no risk of systemic toxicity, facial freezing, or muscle paralysis, ensuring high consumer acceptance.
$\ge 98\%$ Purity Assurance: Produced under strict cosmetic GMP standards, ensuring minimum impurities and optimal biocompatibility.
Warning for Formulators: Always avoid combining Acetyl Hexapeptide-8 with strong acids, strong bases, or powerful oxidizers within the same phase, as they can break down the peptide chain and compromise product stability.
Recommended Dosage: 0.05% - 0.5% (for pure powder); 3.0% - 10.0% (if pre-dissolved into a 1-g/L standard liquid solution).
Solubility: Highly soluble in water and hydrophilic mixtures.
Optimum pH Range: Best maintained between pH 3.0 to 6.0 in final formulations to guarantee long-term molecular stability.
Processing Temperature: Should be added during the final formulation step (post-emulsification) at a temperature below 40°C.
Standard Packaging: 1g, 10g, 50g, 100g, or 1kg per aluminum foil bag / sealed bottle. Bulk industrial packaging available upon request.
Storage Conditions: Store in a cool, dry, dark place. For long-term preservation, keep tightly sealed at -20°C or lower.
Documentation Support: Complete Technical Data Sheets (TDS), Method of Analysis (MOA), Certificates of Analysis (COA), and MSDS are instantly provided upon request.
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