Acetyl Octapeptide-3 (CAS 868844-74-0), widely known by its commercial name SNAP-8, is an advanced, elongation peptide derived from the world-renowned anti-wrinkle peptide Acetyl Hexapeptide-8 (Argireline). By adding two additional amino acids to the original hexapeptide chain, SNAP-8 offers enhanced stability and superior efficacy in reducing the depth of wrinkles caused by facial expression muscle contractions.
As a premier cosmetic peptide manufacturer, we supply ultra-pure >98% Acetyl Octapeptide-3 powder under strict GMP-compliant conditions. It serves as a flagship active ingredient for global cosmetic brands specializing in premium anti-aging serums, high-performance eye creams, and lifting lotions.
Acetyl Octapeptide-3 works by mimicking the N-terminal end of SNAP-25, a critical protein required for the assembly of the SNARE complex (Soluble NSF Attachment Protein Receptor).
Competitive Inhibition: When applied to the skin, SNAP-8 competes with natural SNAP-25 for a position in the SNARE complex.
Disrupting Vesicle Fusion: By destabilizing this complex, it prevents the cellular vesicles from efficiently fusing with the cell membrane.
Reducing Acetylcholine Release: This obstruction significantly inhibits the regulated release of the neurotransmitter acetylcholine into the neuromuscular junction.
Muscle Relaxation & Wrinkle Flattening: As a result, muscle contraction signals are safely moderated, relaxing the muscle tissue beneath the skin and significantly smoothing dynamic expression lines (such as deep forehead furrows, crow's feet, and glabella lines).
Enhanced Anti-Wrinkle Performance: Clinical in-vivo data indicates that SNAP-8 reduces wrinkle depth by up to 34.9% within 28 days, showcasing an approximate 30% efficiency increase compared to its predecessor, Argireline.
Non-Toxic Botox Alternative: Offers a topical, pain-free, and non-invasive solution for consumers seeking professional anti-aging results without the risks of injection-related side effects.
Outstanding Dermal Stability: Its elongated 8-amino-acid sequence provides improved thermal and molecular stability, translating into a longer shelf-life for retail formulations.
Excellent Water Solubility: Effortlessly dissolves in aqueous phases, minimizing processing times and compatibility friction during large-scale manufacturing.
Formulation Tip: To maintain the structural integrity of the octapeptide chain, avoid combining Acetyl Octapeptide-3 in the same phase with high concentrations of strong electrolytes, aggressive chelators, or harsh chemical oxidizers.
Recommended Use Level: 0.05% - 0.5% for pure powder; 3.0% - 10.0% if using a 1-g/L commercial liquid solution.
Solubility Profile: Highly soluble and transparent in water and hydrophilic cosmetic carriers.
Optimal pH Stability: Best formulated and maintained within a pH 3.0 to 6.0 range.
Temperature Constraint: Incorporate during the post-emulsification or final cool-down phase of manufacturing at a temperature under 40°C.
Packaging Solutions: 1g, 10g, 50g, 100g, or 1kg per high-grade sealed aluminum foil bag or medical-grade HDPE bottle. Bulk customized shipping available for commercial contract manufacturing.
Storage Environment: Store in a cool, dry, dark environment. For prolonged manufacturing cycles, keep tightly sealed and preserved at temperatures below -20°C.
Compliance Documentation: Material Safety Data Sheets (MSDS), Certificate of Analysis (COA) per batch, Technical Data Sheets (TDS), and full heavy metal testing reports are available immediately upon customer inquiry.
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